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Code βBF2022β for massive savings ends TONIGHT!!! Get this once a year sale now before it ends!
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Some amazing Black Friday deals from Steroidify.
Simply visit link and take advantage while you can:
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Hello again, guys.
Still not 100%.
Most people are being able to access with TOR browser, so please try it if our site is not loading up properly on your current browser.
Thank you.
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Ursolic acid is a pentacyclic triterpenoid first identified in apple waxes as early as 1920, but can also be found in the peels of many fruits, as well as in herbs and spices like rosemary, basil, oregano and thyme. It's more commonly used today in cosmetic products due to its ability to improve the appearance of wrinkles and age spots by restoring the skin's collagen structures and its elasticity.
As we've seen, Ursolic acid is not a new compound. In fact, there are studies dating back to the 1940s. Its properties regarding the cosmetic features and its ability to promote apoptosis (the death of certain cancer cells) have been established at this point, but what we're really interested in is its potential as a bodybuilding supplement.
Possibly, the first study we should look at was published in 2011, in which researchers used a "connectivity map" to search for compounds with anti-catabolic properties. More than 1300 compounds were tested and Ursolic acid rose to the top as a powerful inhibitor of the genes associated with muscle atrophy. Following this, several other studies (done with mice), have shown that Ursolic acid is not only capable of preventing catabolism under stressful situations (i.e., fasting), but it is also capable of increasing muscle mass and alter the proportion between brown and white fat deposits in the body while reducing overall fatness. As we know, brown fat cells are more easily oxidized and converted into usable energy by the body.
A quick resume of these results can be seen in the image below:
To summarize the benefits of supplementing with Ursolic acid, we put together the following list:
- Decreases markers of skeletal muscle damage during resistance training, thus reducing training-induced muscle tissue breakdown;
- Reduced catabolism even under stressful situations;
- Positive effects on individuals with metabolic syndrome;
- Improved insulin sensitivity;
- Decreased inflammation;
- Increased muscle mass and strength (when compared to weight-training alone);
- Higher rates of non-shivering thermogenesis (utilization of fats for fueling the body);
- Improved levels of irisin in blood (higher levels of irisin makes fat cells more thermogenic);
- Extended the activity of signaling pathways, including mTORC1 for a longer period of time (up to 6 hours after resistance training, where the control group had already fallen to baseline level);
- Decreased diet-induced obesity, glucose intolerance and fatty liver disease;
- Growth inhibition of some types of cancer cells.Although the human trials are lacking, the typical dose seems to be 150mg three times a day, together with larger meals. Here we can observe perhaps what is keeping Ursolic acid from reaching its enormous supplement potential: the poor bioavailability. It's estimated that only about 1% of a dose is actually absorbed.
Efforts are being made right now to improve its bioavailability, with possible solutions including the use of cyclodextrins and reducing the particles to nanometers in size. Unfortunately, neither of these technologies is viable at the moment for the supplementation industry. Another possible solution is to utilize its transdermal form, but there's also a high cost associated with that and its effectiveness is yet to be proven.For now, the options available for those willing to try this supplement are the pharma products available Ursacol by Zambon, Ursofalk by Falk Pharma, among others or by buying it in bulk, assuming you have a trusted supplier. Β
https://steroidify.com/products/ursofalk
For more articles like this, please visit our blog:
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Hi friends.
Our site has beenΒ under unusually heavy ddos attack since Sunday afternoon and all protection systems kick in to keep site up.
But the attackers often use IPs from areas where most people order from, especially within the US.
This causes our cloud service to automatically ban some of these IPs.
So, if you're having problems to access our site, please clean cookies, use a different browser and/or change country on your VPN.
This should work for most cases. If you're still having problems, please let me know your email address registered on our site privately and I can pass the info to our tech team and they can manually give you access.
Sorry for the inconvenience. Should be back to 100% in next few hours or maybe couple of days.Β
The Steroidify Team. -
Initially approved by the FDA back in 2017 for controlling type II diabetes in adults, semaglutide is a drug that belongs to the group of the GLP-1 (glucagon-like peptide 1) analogues. This group of substances has the ability to mimic the body's response after eating a meal, including feeling full, as well as regulating insulin response and altering gastric emptying. Before that, liraglutide, another GLP-1 analogue, had been approved by the FDA in 2010 under the brand name Saxenda.
Clinical studies involving semaglutide showed that patients on it were also losing weight, somewhere in the neighborhood of 11lbs over the course of three months. While that may not seem like much, this loss in body weight came with no dietary modifications, so take a moment and just imagine how powerful this drug can be if paired with a moderately aggressive caloric deficit.
As a matter of fact, users have reported losing 15 up to 20% of total bodyweight in that same timeframe when taken in conjunction with proper dieting and training. That's huge! If we take a 200lbs individual, we're talking about some 30lbs of weight (mostly fat, if the other variables are optimal) lost in three months.
Naturally, as this new drug hit the market under the brand names Ozempic and Wegovy, both from the Danish pharmaceutical company Novo Nordisk, we are seeing a tremendous interest in it coming from bodybuilders, fitness fanatics, soccer moms and just about anybody looking to lose weight. Ozempic is originally meant for type II diabetes control, while Wegovy was formulated more specifically for its weight loss capabilities.
Individuals taking semaglutide (or other GLP-1 analogues for that matter) can expect the following benefits:
- Once-a-week subcutaneous application;
- Loss of appetite;
- Controlled insulin levels even with higher glycemic loads;
- Easier to stay on diet;
- Especially helpful for overweight or obese individuals;
- Slower gastric emptying (feel full for longer). ΒWe all know there's no free lunch, soΒ you can expect as possible side effects:
- Moderate Nausea, vomiting, constipation, diarrhea and abdominal discomfort;
- Liver issues if individual is prone to it;
- Prolonged use may cause pancreas amylase levels to rise;
- Drug withdrawal has to be done slowly and gradually;
- May cause hypoglycemia since you won't feel the need to eat as often;
- Aggressive rebound, meaning if you go back to eating as you did before you'll most likely gain the weight back;Personally, the way I see these GLP-1 drugs is as a tool to help you adhere to a better diet and lose fat, especially if you are overweight or obese. Its use should be limited to a certain period of time, paired with proper dieting and training, and discontinued as you reach a better physique, not as something that allows you to eat whatever. As such, it's very powerful and can yield amazing results.
For more articles like this, visit our blog:
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If you have ever watched Pumping Iron, the famous documentary from the 1970s, you probably remember witnessing Arnold Schwarzenegger smoke a joint as he celebrated the winning of his 1975 Mr. Olympia title.
As it happens, marijuana usage and bodybuilding are tightly correlated and have been this way for several decades. The question is: how does marijuana affect bodybuilding?
Cannabinoids, such as tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN) and cannabigerol (CBG) affect the endocannabinoid systems (ECS) CB1 and CB2 receptors. The ECS is a complex biological system that regulates sleep, recovery, pain, appetite, inflammation, immune system, among many other processes. Cannabinoid receptors are present in both muscle and fat tissues, as well as in many organs throughout the human body.
We will go over some of the more relevant considerations regarding cannabis usage:
Β Β Β Testosterone: just as a quick recap, we know higher levels of testosterone usually result in higher muscle mass, lower body fat, increased libido, improved mood, increased memory, reasoning and spatial abilities, stronger bones, possible better heart health and blood, among other benefits. To cut it short, there have been only a handful of studies and trials trying to find a relationship between weed and testosterone levels, and there is just no consensus yet. Apparently, when you start consuming marijuana, testosterone levels tend to fluctuate a little bit, either higher or lower than before, but that tends to stabilize at around the same level of testosterone you had before using weed as get used to it.
Β Β Β Appetite: if you are bulking, it can get pretty hard to ingest all the calories you need daily. Marijuana can help with that, as the CB1 receptor plays a major role in appetite regulation, given you find the right strain for you. However, it is noteworthy that, for some individuals, CB1 downregulation occurs after some time of prolonged and chronic use, meaning a possible decrease in appetite, which can also be helpful if we are talking about an individual that packs on weight more easily.
Β Β Β Relaxation: One issue is that of relaxation and whether it can alter your performance. Weed use may cause: decreased reaction time, impaired hand-eye coordination, reduced focus, lower stamina and exercise capacity. However, these only happen if you use cannabis before you train. You may find marijuana useful if you are about to embark on a low and slow cardio session. However, you should avoid it if you are about to complete a weightlifting session. Also, a study published in the Clinical Journal of Sport Medicine in 2018, concluded that cannabis did not improve performance.
Β Β Β Inflammation and recovery: as counterintuitive as it may sound to some, inflammation is part of progressing in weightlifting. We actually require the process if we want muscle growth, as it signalizes the body to become bigger and stronger. The times when it becomes a concern is when we are constantly inflamed, which is more and more common specially with daily stress. When this happens, the body doesn't have a chance to restore itself to a state of equilibrium. The ECS, as mentioned before, is involved in the body's inflammatory response, and cannabis stimulates it. Therefore, smoking marijuana and resting could help dramatically reduce the pains and aches one feels after a hard training session and a stressful day.
It's important to note that, while these aspects are generalist and will probably happen to some degree no matter what you choose, different strains of marijuana have a wide, varying range of properties and effects, so it will take some trial and error (or at least a good amount of reading) before finding the one that works best for you, should you decide to try it.
The method of delivery is also important to your end results. Smoking weed, as with all forms of smoking, will cause harm to your lungs for example, but are the more practical and common way of consuming it. You can also choose to vape it, use oils/extracts or cook with marijuana for the effects discussed in this article.
Also, if you plan to use weed, check your local laws, your job's policies and any relevant rules/codes of conduct if you practice any form of competitive sports.
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Prebiotics are substances that nourish specific microorganisms in theΒ intestine, favoring the growth of populations of beneficial bacteriaΒ (generally the prebiotics are polysaccharides and oligosaccharides).
Β Β Β
* They stimulate the increase in the population of bacteria suchΒ as bifidobacteria and lactobacilli, responsible for the fermentationΒ process in the colon.
* They produce a decrease in the stomach pH, managing to control the populations of the most harmful microorganisms.
* At the blood level, they have various functions such as the reductionΒ of cholesterol, triglyceride and phospholipid levels, the absorption ofΒ minerals and the reduction of glucose levels, among others.
* They improve intestinal defenses against intestinal infections.
* They reduce the time of intestinal transit and have a laxative effect,Β which can lead to diarrhea or an upset stomach if the dose is notΒ properly regulated.We have the following types of prebiotics:Β Β Β
* Inulin: It is a dietary fiber.
* Oligofructose: it is obtained by the enzymatic hydrolysis of inulin.
* Pectic substances
* Galacto-oligosaccharides (GOS)
* Fructo-oligosaccharides (FOS)The effectiveness will depend on two factors:
The type of oligosaccharide selected although the average dose to increase the population of bifidobacteria is 15g/day.
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